About my study
1. Biomimetic Chemistry
Progress in modern biochemistry is very remarkable. In "biomimetic chemistry" which attempts to artificially embody the mechanism of biological reactions, the most active thing now is the development of a catalytic reaction modeled on enzymes.
The characteristic of the enzymatic reaction is that the enzyme recognizes and discriminates the substrate matched it (as it can be compared to the relationship between the key and the keyhole), incorporates it, and produces a complex having a specific structure.
"Host-guest chemistry" which artificially realizes host-guest phenomenon was born so as to artificially reconstruct the structure of the biological function modeling the living body and to utilize it more efficiently than the original system.
2. Macrocyclic host compound
Host-guest phenomenon was known since the middle of the 19th century.
In the 1960's, It became clear that cyclodextrin incorporated hydrophobic molecules into the pores in aqueous solution, and the hydroxyl group at the periphery of the ring has a catalytic action peculiar to the guest's hydrolysis, it has the function similar to enzymes.
Similar to cyclodextrin, the cyclophane is the host which having a hydrophobic hole. The first example was reported in 1955.
At the same time, crown ether, which is a kind of macrocyclic polyether, was isolated. It incorporates alkali metal ions into the pores in a non-aqueous solution to form stable complexes.
3. Cleft type host compound
Recently, in addition to the conventional macrocyclic host, it was reported that a ring-opening compound also exhibits a host function. In 1990, schneider designed and synthesized an allosteric ring-opening compound.
Currently, our laboratory is synthesizing cleft-type receptors, and considering application to catalytic reactions.
Progress in modern biochemistry is very remarkable. In "biomimetic chemistry" which attempts to artificially embody the mechanism of biological reactions, the most active thing now is the development of a catalytic reaction modeled on enzymes.
The characteristic of the enzymatic reaction is that the enzyme recognizes and discriminates the substrate matched it (as it can be compared to the relationship between the key and the keyhole), incorporates it, and produces a complex having a specific structure.
"Host-guest chemistry" which artificially realizes host-guest phenomenon was born so as to artificially reconstruct the structure of the biological function modeling the living body and to utilize it more efficiently than the original system.
2. Macrocyclic host compound
Host-guest phenomenon was known since the middle of the 19th century.
In the 1960's, It became clear that cyclodextrin incorporated hydrophobic molecules into the pores in aqueous solution, and the hydroxyl group at the periphery of the ring has a catalytic action peculiar to the guest's hydrolysis, it has the function similar to enzymes.
Similar to cyclodextrin, the cyclophane is the host which having a hydrophobic hole. The first example was reported in 1955.
At the same time, crown ether, which is a kind of macrocyclic polyether, was isolated. It incorporates alkali metal ions into the pores in a non-aqueous solution to form stable complexes.
3. Cleft type host compound
Recently, in addition to the conventional macrocyclic host, it was reported that a ring-opening compound also exhibits a host function. In 1990, schneider designed and synthesized an allosteric ring-opening compound.
Currently, our laboratory is synthesizing cleft-type receptors, and considering application to catalytic reactions.